4-BUTOXY-3,5-DICHLOROPHENYLBORONIC ACID - Names and Identifiers
4-BUTOXY-3,5-DICHLOROPHENYLBORONIC ACID - Physico-chemical Properties
Molecular Formula | C10H13BCl2O3
|
Molar Mass | 262.93 |
Storage Condition | Sealed in dry,2-8°C |
Sensitive | IRRITANT |
MDL | MFCD15143476 |
4-BUTOXY-3,5-DICHLOROPHENYLBORONIC ACID - Introduction
(4-Butoxy-3,5-dichlorophenyl)boronic acid is an organic boron compound with the chemical formula C10H12BCl2O3. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
(4-Butoxy-3,5-dichlorophenyl)boronic acid is a solid substance with a white to light yellow crystalline form. It has low solubility in water and good solubility in organic solvents (such as ethanol, dichloromethane, etc.). It can be stable in the air, but encounter high temperature, high pressure, fire source can lead to its decomposition.
Use:
(4-Butoxy-3,5-dichlorophenyl)boronic acid is an important intermediate in organic synthesis, commonly used in metal-catalyzed reactions. It can be used as a ligand to participate in palladium-catalyzed Suzuki coupling reaction, palladium-catalyzed Heck coupling reaction, palladium-catalyzed C- H activation and other synthetic reactions. In addition, it can also be used to prepare organic compounds such as drugs and pesticides.
Preparation Method:
(4-Butoxy-3,5-dichlorophenyl)boronic acid is usually prepared by reacting the corresponding substituted phenyl bromide or chloride with boronic acid. A common method of preparation is the reaction of 3,5-dichlorophenylcarboxylic acid with 1-bromobutane to give the corresponding substituted product under base catalysis. Then, by acid hydrolysis, the final (4-Butoxy-3,5-dichlorophenyl)boronic acid can be obtained.
Safety Information:
(4-Butoxy-3,5-dichlorophenyl)boronic acid has low toxicity, but as an organic compound, it still needs to be properly handled. It is not stable at high temperature, high pressure and fire sources, and should avoid contact with strong oxidants. In the use of the process, should try to avoid skin contact and inhalation of its dust or steam. Appropriate personal protective equipment such as lab gloves, goggles and protective masks should be used during operation.
In addition, it is best to check the relevant safety data form before use, and operate and handle it under the guidance of proven experience.
Last Update:2024-04-09 21:32:53